The relatively high rate of actionable gene alterations—including those of rarer genes—observed in our study is most likely due to the referral nature of many patients, which results in a positive selection of cases with a higher probability to be found with driver alterations (e.g., never-smokers with previously diagnosed negative EGFR mutational status accessing our institution for wider tumor genomic profiling). The gene discussed is EGFR; the disease is neoplasm.