Pparγ1 deletion reduced expression of Pparγ1 target genes, genes governing growth factor signaling pathways (EGF, IRS2, AngP2, CXCl5, SDF2), transcription factors that promote breast tumor growth including nuclear receptors and anabolic solute carriers (Slc25a35 (oxaloacetate carrier), Slc39a13, Slc39a14, Slc15a5, Slc18a1, Slc17a7) which may participate in cellular growth [72]. The gene discussed is IRS2; the disease is breast neoplasm.