Other rare genetic events directly involving NF-kB include chromosome 10q24 rearrangements that lead to loss of the 3′-end of NFKB2 (encoding p100) and constitutive protein activation [154], and amplifications of REL (encoding c-Rel), which are mostly seen in GCB DLBCL [9]. This evidence concerns the gene REL and diffuse large B-cell lymphoma.