NFKB1 and neoplasm: In addition, EVs derived from CSC-rich colonospheres were found to contain 5′-triphosphate RNA that activates NF-kB in neutrophils and increase interleukin-1 beta (IL-1β) secretion, leading to prolonged neutrophil survival as well as promoted tumor cell survival in the primary TME and peritoneal spreading of tumor cells in vivo.