EVs secreted from epithelial ovarian cancer (EOC) tissue explants, ovarian cancer cell lines (OVCAR-3 and SKOV-3) and ascitic fluid from EOC patients were analyzed for their role in immunosuppression via two pathways involved in anticancer immunity, NKG2D receptor-ligand and DNAM-1-poliovirus receptor (PVR)/nectin-2 [132]. The gene discussed is PVR; the disease is ovarian carcinoma.