The proliferation rates of cancer cells is increased by production of growth factors, upregulation of growth factor receptors or activation pathways downstream of growth factor stimulation and each of these can increase MV release, through dysregulation of MV-biogenesis via activating the small GTPases RhoA and ADP-ribosylation factor 6 (Arf6) [19,20,21]. Here, ARF6 is linked to cancer.