These studies of intra-tumour heterogeneity in ccRCC reported patterns of convergent phenotypic evolution in several genes including VHL, BAP1, SETD2, PBRM1, PIK3CA, PTEN, and KDM5C [2,4], which were also among the most frequently mutated genes in our cohort. This evidence concerns the gene KDM5C and nonpapillary renal cell carcinoma.