The two most striking pathway pairs include “major pathway of rRNA processing in the nucleolus and cytosol” (pathway 1), which is clonally exclusive with “O-glycosylation of TSR domain-containing proteins” (pathway 2) and “defective B3GALTL causes Peters-plus syndrome (PpS)” (pathway 3) (Figure 4A). The gene discussed is B3GLCT; the disease is popliteal pterygium syndrome.