Simultaneously, upstream factors of NOS2 and PGE2, including p38, NF-κB, c-fos and COX-2, were inhibited in LPS-stimulated macrophages with TGII treatment, suggesting that a possible therapeutic approach to inflammatory diseases such as sepsis may focus on anti-inflammatory agents to suppress the proinflammatory response. The gene discussed is FOS; the disease is Sepsis.