As CMC2.24 has already demonstrated safety in vivo, using models of diabetes and periodontitis, as well as stability and bioavailability that were both superior to curcumin, our results of greatest inhibitory effects on tyrosinase activity and melanin production by CMC2.24 establish that this compound merits use for repurposing for the treatment of hyperpigmentation disorders. The gene discussed is TYR; the disease is diabetes mellitus.