PRNP and scrapie: The elongation of the incubation time of about 18% (240 vs 202 days) observed here is in a similar range compared to other immunisation strategies: immunisation with murine PrP linked to Keyhole Limpet Hemocyanin (KLH) prior to infection prolonged incubation time by 11.2% for scrapie in mice [50] and scrapie infected mice that were vaccinated with aggregated murine PrP (suspended in complete Freund’s adjuvant) survived approximately 28 days longer than naive mice [51].