The role of methylation in MAL gene silencing was supported by restoring MAL mRNA levels in tumor cell lines after treatment with 5-aza-2′-deoxycytidine, which inhibits DNA methylation, combined or not with trichostatin A, which is an inhibitor of deacetylation [197,200,201,202,204,208,209,211,219,220,221]. Here, MAL is linked to neoplasm.