In a number of cell lines without endogenous MAL expression derived from different types of cancer (Table 2), the exogenous expression of MAL limits a number of cancer progression-related cell activities, such as migration in wound-healing assays, invasion in Matrigel®, proliferation, colony formation in soft agarose, tumorigenicity in inoculated nude mice, and increases in the level of apoptosis relative to that in the parental cells [200,201,202,210,219]. Here, MAL is linked to cancer.