The randomized phase 2 trial DESTINY-Gastric01 evaluated T-DXd compared with chemotherapy in patients with HER2-positive advanced gastric or gastroesophageal junction adenocarcinoma who had progressed on at least two previous therapies, including trastuzumab (NCT03329690) [30]. The gene discussed is ERBB2; the disease is gastroesophageal junction adenocarcinoma.