PRKN and cancer: In support of the role of mitophagy in cancer chemoresistance, it has been reported that the inhibition of PINK1/Parkin-dependent mitophagy through PINK1 siRNA, mdivi-1, or bafilomycin A1 (Baf A1) promotes B5G1-induced cell death, sensitizing multidrug-resistant cancer cells to a new betulinic acid analog, B5G1 [108].