The importance of VDAC1 has also been reported in chemoresistant cancer patients since a truncated but channel-forming isoform of VDAC1 (VDAC1-ΔC) has been detected in late-stage tumor tissue and tissues from chemoresistant lung adenocarcinoma patients; these findings demonstrate that VDAC1-ΔC is induced by HIF-1 in hypoxic conditions, conferring protection from apoptosis [198,199,200]. Here, VDAC1 is linked to lung adenocarcinoma.