The majority of follicular neoplasms can occur as sporadic cases, but some inherited syndromes such as Brooke–Spiegler (autosomal dominant disease (AD), the mutation is in CYLD (CYLD Lysine 63 Deubiquitinase) suppressor gene), Gardner’s syndrome (AD, the mutation in APC (adenomatous polyposis coli) suppressor gene), Cowden syndrome (AD, germline mutation in PTEN (phosphatase and tensin homolog) suppressor gene), and Rombo syndrome (unknown etiology) can predispose people to them [3,4,5,6,7]. The gene discussed is PTEN; the disease is Cowden disease.