NCOA3 and breast carcinoma: The SRC-3 gene was first cloned from BT-474, a breast cancer cell line that contains high copy of chromosome 20 [5], five groups subsequently characterized SRC-3 as a coactivator, belonging to SRC family (AIB1, ACTR, RAC-3, pCIP, TRAM-1) [6,7,8,9,10].