Recently, Dasgupta et al. demonstrated that the phosphorylation of SRC-3 induced by PFKFB4 increased its interaction with the transcription factor ATF4 to promote transcriptional reprogramming and aggressive metastatic cancer by stabilizing the recruitment of SRC-3 and ATF4 to downstream gene promoters [30]. This evidence concerns the gene NCOA3 and metastatic malignant neoplasm.