BCAT1 has been implicated in leukemia stem cell (LSC) metabolism as its overexpression decreased intracellular αKG levels and caused DNA hypermethylation through altered TET activity; AML with high levels of BCAT1 displayed a DNA hypermethylation phenotype similar to cases carrying a mutant IDH [54,55]. This evidence concerns the gene IDH2 and acute myeloid leukemia.