ALFY encodes a phosphatidylinositol 3-phosphate-binding protein, which acts as scaffold protein to facilitate selective autophagy-mediated removal of aggregated intracellular proteins and clearance of mitochondria via mitophagy; a dominant missense mutation of ALFY, has been linked to microcephaly through clearance of DVL3, a target of the canonical Wnt signaling pathway [126]. The gene discussed is WDFY3; the disease is microcephaly.