TP53 and glioma: To investigate the mechanism of action of aging-related genes in gliomas, we conducted GSVA analysis, and identified common biological functions of aging-related genes in development and tumorigenesis of gliomas, including P53 signaling pathway, DNA damage response, natural killer cell mediated cytotoxicity, tumor necrosis factor (TNF)-mediated signaling pathway, which are consist with previous studies [35, 36].