The expression levels of ARNTL, FBXO4, CHEK1, CHEK2, CTSC, MBD2, HMGA2, IGFBP2, TIMP1 were higher, while EEF2 expression was lower in GBM tissues compared to LGG (Low-grade gliomas) tissues (Figure 2D). Here, IGFBP2 is linked to central nervous system cancer.