In the multivariate analysis, ZBTB7C, as a tumor suppressor gene, was an independent prognostic factor in COAD (hazard ratio = 0.60; 95% confidence interval (CI), 0.39–0.94; P = 0.025; Figure 2E) and MESO (hazard ratio = 0.44); 95% CI, 0.24–0.78; P = 0.006; Figure 2H). This evidence concerns the gene ZBTB7C and colon adenocarcinoma.