The results showed that, on the one hand, the expression of ZBTB7C was negatively correlated with TMB in BRCA (r = -0.138, p < 0.001), ESCA (r = -0.157, p = 0.048), LUAD (r = -0.397, p < 0.001), LUSC (r = - 0.099, p = 0.029), PRAD (r = -0.362, p < 0.001), sarcoma (SARC) (r = -0.221, p < 0.001) and skin cutaneous melanoma (SKCM) (r = -0.264, p < 0.001). Here, ZBTB7C is linked to cutaneous melanoma.