Among all the genes, CCNB1 was the most important node with the highest degree, which was regulated by a total of 19 transcription factors, including several important tumor-associated genes, such as BRCA1, MYC, TP53, and three E2Fs family members (E2F1, E2F3, and E2F4). The gene discussed is CCNB1; the disease is neoplasm.