In the present study, those cell cycle-related genes such as CDK1, CCNB1, CDC20, NEK2, AURKA, RACGAP1, CDKN2A, CDKN2B, CDKN3, RRM2, and ASPM were significantly upregulated in HCV-HCC. The gene discussed is RRM2; the disease is hepatocellular carcinoma.