Further analysis of HBV-HCC tissue compared to adjacent non-tumor tissue showed altered expression of β-catenin-related proteins, NF-κB signaling components, ribosomal subunits, ubiquitin-related proteins, respiratory complex and metabolism-related protein [43], corroborating changes also detected in the present study (Table 1, Fig. 4). Here, NFKB1 is linked to hepatocellular carcinoma.