IL1B and diabetic retinopathy: In addition, resolvin D1 downregulates the expression of IL-1β via inhibition of NOD-like receptor family proteins such as pyrin domain-1 containing 3 (NLRP3), thereby inhibiting the inflammasome pathway in rats with streptozotocin-induced diabetic retinopathy or hyperhomocysteinemia-induced podocyte injury [22, 23].