There are many target genes of the tumor suppressor function of miR-143-3p in CRC, including Bcl-2, CASP3, CD44, KLF5, KRAS, BRAF, TLR2, SOD1, IGF1R, ITGA6, and ASAP3 [26–32]. The gene discussed is IGF1R; the disease is colorectal carcinoma.