However, although not statistically significant, the proportion of activated M. tuberculosis–specific CD4+ T cells tended to be higher in COVID-19–coinfected patients compared with the non–COVID-19 group (median: 74 %, IQR: 49%–94% vs. 57.7%, IQR: 50%–77%, respectively; Figure 7E). This evidence concerns the gene CD4 and COVID-19.