Only 2 studies have measured the effect of HIV-1 infection on the overall profile of T cells in COVID-19 cases: Karim et al. showed that viremic HIV-infected COVID-19 patients exhibited lower frequencies of tissue-homing CXCR3+ CD8+ T cells and higher T cell activation compared with HIV-uninfected patients (54). The gene discussed is CD8A; the disease is HIV-1 infection.