On the other hand, our ChIRP-seq analysis did not reveal DRAIR-chromatin interactions upstream of other DRAIR target genes validated in this study, such as IL1RN and MCL1. However, several genes located near Dbs (±250 kb), including CHIT1 discussed above, were dysregulated in T2D monocytes (Supplemental Table 3). Here, CHIT1 is linked to type 2 diabetes mellitus.