We found that DRAIR reduces promoter enrichment of G9a and the corresponding repressive mark H3K9me2, along with upregulation of antiinflammatory genes such as IL1RN and CPEB2. This was further supported by our observation that EHMT2 (G9a) knockdown could increase the expression of antiinflammatory genes that are also regulated by DRAIR. Therefore, DRAIR downregulation and G9a upregulation in T2D may act cooperatively in mechanisms associated with downregulation of antiinflammatory pathways in monocytes and chronic inflammation (Figure 10). Here, EHMT2 is linked to type 2 diabetes mellitus.