To examine this further, we performed strand-specific RNA sequencing (RNA-seq) analysis to profile changes in the transcriptome of CD14+ monocytes obtained from human volunteers with T2D (T2D monocytes) relative to control healthy volunteers without diabetes (control monocytes) (Figure 1A and Supplemental Table 1; supplemental material available online with this article; https://doi.org/10.1172/jci.insight.143289DS1). Here, CD14 is linked to diabetes mellitus.