In agreement with a role for CCR10 in the maintenance of MPCs, CRISPR/Cas9–mediated KO of CCR10 in normal and IPF fibroblast cultures caused a dramatic decrease in the numbers of CCR10+SSEA4+ cells, as well as CCR10+EphA3+ cells. Here, EPHA3 is linked to idiopathic pulmonary fibrosis.