We have previously reported that IPF lung fibroblasts (devoid of CD45 and EpCAM (50, 51) induce lung remodeling in SCID-beige mice, but normal lung fibroblasts do not induce any lung remodeling in SCID-beige mice at day 63 after injection (37). This evidence concerns the gene PTPRC and idiopathic pulmonary fibrosis.