EPHA3 and idiopathic pulmonary fibrosis: Although we have previously shown that IPF fibroblasts alone mediate nonresolving lung remodeling in the lungs of mice (37, 63), and the number of Lin–CCR10+ cells positively correlated with hydroxyproline levels in the lungs of mice, KB004 targets EphA3+ cells through an ADCC-dependent mechanism, which relies on the presence of immune cells, specifically NK cells (52, 53).