The in vitro profilingof these sEHIs (solubility, cytotoxicity, metabolic stability, CYP450s, hLOX-5, hCOX-2 and hERG inhibition) allowedto select a suitable candidate for an in vivo efficacystudy in a murine model of AP, for which sEHIs showed effectivenessat ameliorating this condition.19,35,36 The administration of 22 improved the general healthstatus of cerulein-induced AP mice and significantly reduced pancreaticdamage. Here, PTGS2 is linked to alkaline phosphatase measurement.