APP and Alzheimer disease: AD showed very complex disease etiology which is characterized by majorly two hallmarks, first is the association of amyloid β plaques which is formed by the abnormal cutting of amyloid precursor protein (APP) while another hallmark is the neurofibrillary tangles (NFTs) being formed by the association of hyperphosphorylated microtubule-associated binding protein (MAPT) [2, 3].