IGHE and food allergy: It has long been understood that IgE-mediated food allergies result from a type 2 helper T cell (Th2) immune response of the adaptive immune system to protein antigens associated with specific foods (Akdis, 2006; Chiang et al., 2018; Sampson et al., 2018; Turcanu et al., 2003; Wambre et al., 2017; Wisniewski et al., 2015; Yu et al., 2016).