Specifically, we previously showed that the abundance of the microbial gene encoding for the choline trimethylamine-lyase (cutC) responsible for production of the disease-associated trimethylamine and trimethylamine N-oxide (Kalnins et al., 2015; Kummen et al., 2017; Oellgaard et al., 2017; Rath et al., 2017) (TMA/TMAO) is significantly higher in CRC patients (Thomas et al., 2019). This evidence concerns the gene CUTC and colorectal carcinoma.