CUTC and colorectal carcinoma: HUMAnN 3 was instead able to directly profile relative abundances of 113 UniRef90 gene families annotated as cutC orthologs and identified 909 metagenomes in this data collection carrying at least one gene family annotated as cutC. These confirmed an increase of cutC relative abundance in CRC samples compared to controls (Wilcoxon rank-sum test p<0.05 in six of the nine datasets, meta-analysis p<0.0001).