However, there were still some open questions that need to be taken into consideration in our future study, like which downstream target gene(s) of MALAT1/miR-188-5p to affect MM cell activities, whether MALAT1 contains different MREs of other miRNAs and also whether miR-188-5p shares MREs with other transcriptome. This evidence concerns the gene MALAT1 and Miyoshi myopathy.