NOTCH3 and CADASIL: Currently, more than 200 pathogenic mutations in the NOTCH3 have been reported to cause CADASIL, and the majority are missense mutations distributing in exons 2–24, changing the number of cysteines in the EGFr domains, resulting in an odd number of cysteines in the ECD of the receptor, causing incorrect protein folding and aggregation.9, 10