Subsequently, Muiño et al. conducted a systematic review of cysteine‐sparing NOTCH3 missense mutations in clinically suspected CADASIL patients in 2017 and believed that only four (p.R61W, p.R75P, p.D80G, and p.R213K) were possible pathogenic mutations, while the remaining 21 cysteine‐sparing mutations, including p.V237M and p.A1020P, lacked convincing evidence of pathogenicity because of atypical CADASIL phenotype, relatively high frequency in a public database, no GOM deposition in the skin biopsy, or other pathogenic mutations that cannot be ruled out due to incomplete exons sequencing.11 Here, NOTCH3 is linked to CADASIL.