SAMSN1, SLC39A8, SMPDL3A, and FABP5 were positively correlated with malaria phenotype/severity and showed an upregulation in the CM group compared with healthy controls, while MBP, SPSB3, PSMF1, SHARPIN, EIF3B were negatively correlated with malaria severity and downregulated in the DEG (Figure 3C and Table 1). This evidence concerns the gene SPSB3 and malaria.