However, the diagnosis of AD has not been standardized, and the main diagnostic methods include MRI and PET brain imaging, biochemical analysis of Aβ42/40, and total tau (t‐tau) and phosphorylated tau (p‐tau181) levels in the cerebrospinal fluid (CSF) (Bocchetta et al., 2015; Rice & Bisdas, 2017; Ritchie et al., 2017). This evidence concerns the gene MAPT and Alzheimer disease.