SERPINA1 and Alzheimer disease: In addition, Aβ‐related protein ADAM10 was found to be strongly correlated with complement activation‐related protein SERPINA1 and platelet activation‐related protein integrin alpha‐IIb (ITA2B) (| r | =0.70–0.85) (Figure 5a; Excel S4), suggesting that the three may play a coordinated or antagonistic role in the pathogenesis of AD.