The brain and platelets contain high concentrations of APP, and during AD, the non‐amyloidogenic pathway enzyme disintegrin and metalloproteinase domain‐containing protein 10 (ADAM10) are down‐regulated and the amyloidogenic pathway enzyme BACE1 is up‐regulated (Colciaghi et al., 2002). This evidence concerns the gene ADAM10 and Alzheimer disease.