Several of the proteins associated with ALS/FTD, including TDP-43 (also known as TARDBP), FUS, TAF15, EWSR1, HNRNPA1 and HNRNPA2, are RNA-binding proteins (RBPs) that also contain a prion-like domain (PrLD) (Cushman et al., 2010; Harrison and Shorter, 2017; King et al., 2012). This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.