Importantly, these NIR activities are cytoprotective in vivo, as upregulation of Kapβ2 can prevent motor neuron degeneration elicited by ALS-linked FUS and muscle degeneration conferred by disease-linked HNRNPA2 (Guo et al., 2018). This evidence concerns the gene HNRNPA2B1 and amyotrophic lateral sclerosis.