As QKI is one of the genes most associated with various neurological diseases (Darbelli and Richard, 2016), understanding the mechanisms underpinning Qki/Srebp2-mediated cholesterol biosynthesis and myelination will help identify tissue-specific therapeutic opportunities for neurological diseases associated with myelin defects (Nwokoro et al., 2001; Porter and Herman, 2011). The gene discussed is SREBF2; the disease is nervous system disorder.