Of note, among the 108 schizophrenia-associated genomic loci, one is on chromosome 22q13.2, which includes SREBF2 gene that encodes sterol regulatory element-binding protein 2 (SREBP2), the major transcription factor that regulates cholesterol biosynthesis (Horton et al., 2002; Le Hellard et al., 2010; Steen et al., 2017). This evidence concerns the gene SREBF2 and schizophrenia.