SC5D and hereditary disease: For example, hereditary diseases such as Smith–Lemli–Opitz syndrome (SLOS), desmosterolosis, and lathosterolosis are caused by mutations of the cholesterol biosynthesis genes encoding 7-dehydrocholesterol reductase (DHCR7), 24-dehydrocholesterol reductase (DHCR24), and sterol-C5-desaturase (SC5D), respectively (Kanungo et al., 2013; Nwokoro et al., 2001; Porter and Herman, 2011).