We then analyzed the correlation between XIST expression and pathological characteristics of RB patients through Chi-square test, and the data implied that there was no significant correlation between XIST expression and gender or age of the patients, whereas significant correlation was observed between XIST expression and tumor size, choroidal nerve invasion, optic nerve invasion, and tumor staging, indicating that XIST partook in the progression of RB (Table 2). Here, XIST is linked to retinoblastoma.