The PI3K pathway, on the other hand, relays its signal to multiple pathways to include RHO GTPases and the NFκB‐, SH1P‐ and AKT pathways and results in migration, inflammation and proliferation of cells.13, 14 In this study, the PI3K/AKT pathway was examined as a potential therapeutic intervention point for IBD. This evidence concerns the gene RHO and inflammatory bowel disease.