CD4 and neoplasm: Priming autologous CD4 and CD8 T‐cell responses against tumors may fail due to several reasons: loss of cell surface HLA receptors; lack of TSAs, especially in tumors with a low tumor mutational burden; establishment of an immunosuppressive tumor microenvironment through the presence of myeloid‐derived suppressor cells; CD8 T‐cell exhaustion; and impaired co‐localization and interaction of CD4 T cells, CD8 T cells, and antigen‐presenting cells [2, 3, 4, 5].