Using a gene expression profiling interactive analysis (GEPIA) data set (http://gepia.cancer‐pku.cn/), we found that the expression levels of HIF1A and SESN2 were higher in PAAD than in normal samples (Figure 1A,B), intriguingly, HIF1A was positively associated with SESN2 (Figure 2). Here, SESN2 is linked to pancreatic adenocarcinoma.