In addition, oncogenic Kras driven metabolic reprogramming in pancreas cancer cells utilizes cytokines from tumour microenvironment,13 and tumour‐associated macrophages in tumour microenvironment promote progression and the Warburg effect via the CCL18/NF‐kB/VCAM‐1 pathway in PDAC.14 This evidence concerns the gene VCAM1 and neoplasm.