In the same study, using ddPCR, promoter methylation of these two genes (ST6GALNAC3 and ZNF660) and additionally CCDC181 and HAPLN3 was evaluated in ctDNA of 27 patients with prostate cancer and 10 patients with benign prostate hyperplasia using MS‐ddPCR [51]. Here, HAPLN3 is linked to Familial prostate cancer.