GRM5 and Huntington disease: Five genes (KRAS, CACNA1L, GRIN2A, GRM5, and GABRG2) DE in HD animals versus controls were previously identified in GWAS of AUDs.64 Further, 44 DE genes (Table S7) were previously identified in a microarray study of postmortem human nucleus accumbens comparing individuals with AUDs and matched controls.65 The common genes were present in co-expression modules specifically enriched for different brain-specific cell types and included both neurons and astrocytes.