NOD1 and infection: In context of infection, the assumption of an evolutionary conserved role of NOD1/2 in detecting pathogens or pathogen‐induced cellular stress via NBDs is supported by the finding that the 290 NOD‐like receptors (NLRs) identified in Hydra magnipapillata lack LRRs, but still interact with the death domain (DD) or caspase recruitment domain (CARD)‐containing proteins, resembling inflammasomes in vertebrates (Lange et al,2011).