When we compared in this study the frequencies of SNPs in some BER genes and in the TP53 gene in a cohort of male BC with previously genotyped female BC cases [17, 18, 26], the results indicate significant differences between female and male populations for the XRCC1 rs1799782, MUTYH rs3219489 and TP53 SNPs rs1042522 and rs8064946, suggesting that these genotypes are related with lower susceptibility in males for XRCC1 and TP53 when in heterozygosity, contrasting with high susceptibility for MUTYH. The gene discussed is XRCC1; the disease is breast cancer.