GLP1R and ischemic stroke: Experimental studies conducted in gerbils, mice and rats demonstrated that GLP-1 receptor (GLP-1R) agonists Exendin 4 (Ex4), liraglutide or semaglutide, administered either systemically or centrally, are highly effective in protecting the brain against ischaemic stroke induced by bilateral carotid artery occlusion or middle cerebral artery occlusion [9, 21, 50, 59, 78].