More recent studies provided further pieces of evidence confirming and strengthening the former observations; in particular, in 2011, Braak’s group released the revised classification of neurofibrillary tangles (NFT)-pathology in AD, based on the evaluation of a huge number of AD brains and stated that LC is the first brain structure to show tau-related pathology, decades before neocortical involvement (Braak et al. 2011). This evidence concerns the gene MAPT and Alzheimer disease.