These subjects often show higher glucocorticoids plasma levels, when compared to healthy controls, in parallel with a reduced responsiveness to these hormones (Csernansky et al. 2006); moreover, corticotropin releasing-hormones (CRH) levels are altered in the cerebrospinal fluid of AD patients (Banki et al. 1992) and similar findings have been obtained concerning thyroid hormones. Here, CRH is linked to Alzheimer disease.