Similarly, even though the available evidences concerning the direct functional effects of LC activity upon in TRH (Jaffer et al. 1990) and CRH (Szafarczyk et al. 1985) release are still scarce and contradictory, in this case LC degeneration might be crucial for the occurrence of degeneration neurons of these areas (periventricular nucleus) (see “The loss of neuroprotective effects of LC efferences may enhance AD pathology also in the hypothalamus” section). The gene discussed is TRH; the disease is Alzheimer disease.