Interestingly, in 2013, Zhang and colleagues showed that in the brain of aged mice, the dysregulation of neuroinflammatory pathways leads to the reduction of GnRH production, which parallels cognitive impairment; noteworthy, the exogenous administration of GnRH partially restored such cognitive alterations (Zhang et al. 2013). Here, GNRH1 is linked to Cognitive impairment.