Of 217 treatment-naïve eyes (191patients) that received anti-VEGF therapy for centre-involving DME, 66 eyes were excluded from the study (42 treated with corticosteroids as a first-line therapy, 17 had less than 1 year of follow-up, 6 underwent less than 3 injections and one patient was also affected by AMD). This evidence concerns the gene VEGFA and age-related macular degeneration.