INS and diabetes mellitus: Furthermore, NSD2 has been shown to play a key role in promoting adipogenesis and myogenesis in precursor cells, as well as thermogenesis in brown adipose tissue and insulin sensitivity in white adipose tissue.27 In pancreatic β-cell lines in vitro NSD2 has also been shown to promote proliferation and to regulate insulin secretion.28 However, since diabetes has not been reported as a recurrent feature neither in our cohort nor in patients with WHS we assume that in humans, glycemic control may be maintained despite impaired NSD2 function.