NSD2 and Wolf-Hirschhorn syndrome: The main clinical features of the NSD2 cohort consisting of 18 individuals described here and 10 previously published individuals (8 carrying truncating or protein-elongating variants14–18 and 2 carrying a microdeletion that encompasses the NSD2 gene only10) are summarized in Fig. 3a and compared to patients with WHS due to 4p deletions of different sizes reported in a large series of 166 affected individuals3 (Fig. 3b).