Immunological abnormalities as well as recurrent infections, which represent a common morbidity and mortality cause in WHS,24 were infrequent in the NSD2 cohort, where patient 5-I presented with latex allergy, patient 11-I with low IgA and IgG3 levels, and patients 2-I, 11-I and Derar-1 with recurrent respiratory infections. This evidence concerns the gene IGHG3 and infection.