KLK3 and posterior cortical atrophy: The aim of this prospective, multicenter study was to evaluate the clinical performance of the SelectMDx test and in combination with mpMRI for the detection of high-grade PCa in biopsy-naïve men with an elevated PSA level with an optimized biopsy reference outcome, that is, combined results of transrectal ultrasound-guided biopsy (TRUSGB) with subsequently MR in-bore guided biopsy (MRGB).