In this chain of axis, EphA2 interacts with YES1 and phosphorylates YES1 at Tyr426 site that results in YES1 activation, activated YES1 interacts with ANXA2 and phosphorylates ANXA2 at Tyr24 site that induces ANXA2 activation and increases ANXA2 nuclear distribution, leading to activation of the tumor-promoting transcription factors [33, 35–38] that promotes GC invasion and metastasis (Fig. 7). The gene discussed is EPHA2; the disease is neoplasm.