ANXA2 and neoplasm: Ser phosphorylation of ANXA2 seems to be an essential event of the secretory process [23], while Tyr24 phosphorylation of ANXA2 (p-ANXA2-Y24) has been related to the localization of ANXA2 to the endocytic membrane system and the nucleus, and is associated with malignant transformation, EMT, tumor invasion, and metastasis [23–26].