In further support of its use for OCD research, the Sapap3-KO mouse has abnormalities in OCD-relevant behavioral constructs (compulsive behavior, anxiety, executive dysfunction, and now disruption of sensorimotor gating), and exhibits therapeutic response to treatments that can be effective in OCD patients including repeated fluoxetine administration and deep brain stimulation32, 51. This evidence concerns the gene DLGAP3 and Anxiety.